Apache2 webserver >= 2.2.x with the following Apache modules enabled
rewrite
filter
deflate
headers
expires
MySQL database >= 5.1 (Please note, that translate5 used to run on MSSQL. translate5 still is able to run on other SQL-Databases than MySQL with some testing and smaller adjustments to the code. Please contact the developers, if you need this.)
PHP 5.6 or higher with the extensions installed and enabled